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Han Bingnan - Associate Professor

Date:Monday,January.10

Han Bingnan
Associate Professor, Department of Ocean Science and Engineering
 
 
Phone: +86 571 8827 3045
Fax:   +86 571 8827 3064
Email: hanbingnan@zju.edu.cn
Office: Dept. of Ocean Science and Engineering,
Zhejiang University, Zijingang Campus,
388 Yuhangtang Road, Hangzhou, China, 310058
 
Other Appointments
Visiting Professor,
Department of Medicinal Chemistry and Molecular Pharmacology,
College of Pharmacy, Purdue University, USA
 
Professional Activities
Member, American Society of Pharmacognosy
Member, American Society of Chemistry
Reviewer, Journal of Natural Products
 
Education
Ph.D. – Oregon State University, College of Pharmacy, USA, 2005
M. S – California State University, Northridge, Department of Chemistry, USA, 1999
B.S. – Hangzhou University, Department of Biological Science, China, 1994
 
Working Experience
 
06/2010-- 
Associate Professor, Department of Ocean Science and Engineering, Zhejiang   University
03/2008—05/2010
Research Scientist, Development Therapeutics Program, SAIC-Frederick Inc., NCI-Frederick,
Frederick, MD USA
10/2007—02/2008
Postdoctoral Research Associate, Bindley Bioscience Center, College of Pharmacy, Purdue University, IN USA
07/2005—09/2007
Postdoctoral Research Associate, Center of Mass Spectrometry, Oregon State University, OR USA
Awards and Honors
2005    1st Winner Award Oral Presentation, OSU's 13th Annual Graduate   Student Conference
        Title: Isolation and Structure of Lyngbyabellin Derivatives from a Papua New Guinea   Collection of the Marine Cyanobacterium Lyngbya majuscule
 
2004    1st Winner Award Poster Presentation, 2004 College of Pharmacy, OSU Annual Retreat
          Title: Isolation and Structure of Lyngbyabellin Derivatives from a Papua New Guinea  
          Collection of the Marine Cyanobacterium      
Research Interests
Marine natural products chemistry and mechanism study
Diseases focused Proteomics and Metabolomics study
 
 
Current Projects
1.     Screening, isolation and structure elucidation of anti-cancer compounds from marine cyanobacteria collected from Zhejiang offshore(2010QNA4014)
2.      Screening, isolation and structure elucidation of anti-cancer compounds from marine cyanobacteria Lyngbya semiplena collected from Zhejiang offshore(Y2100044)
3.      Lipidomics study of anandamide recycling on mouse brain tissue
4.      Anti-tumor activity study of natural products isolated from Cyanobatera stigonema sp. collected from Nanji island, China
 
 
Publication List
1.      Bingnan Han, Luke H. Stockwin, Chad Hancock, Sherry X. Yu,Melinda   G. Hollingshead, and Dianne L. Newton. Proteomic Analysis of Nuclei isolated from cancer cell lines treated with Indenoisoquinoline NSC724998, a novel Top1 inhibitor. Journal of Proteome Research 2010:9(8),4016-4027.
2.     Chad N. Hancock, Luke H. Stockwin, Bingnan Han, Raymond D. Divelbiss, Jung Ho Jun, Sanjay V. Malhotra,    Melinda G. Hollingshead and Dianne L. Newton.A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radical Biology and Medicine 2010: Available online 22 October 2010.
3.     Luke H. Stockwin, Bingnan Han, Sherry X. Yu, Melinda G.Hollingshead, Mahmoud A. ElSohly, Waseem Gul, Desmond Slade,Ahmed Galal, and Dianne L. Newton. Artemisinin dimer anti-cancer activity is mediated by heme-catalyzed ROS generation and ER stressInduction. International Journal of Cancer2009:125(6), 1266-1275.,
4.     Bingnan Han, Mike Hare and Claudia S. Maier. A Simple Method ofQuantitative Analysis of Endogenous Oxylipid- Conjugates from Rat Cardiac Mitochondria. (Manuscript in preparation for Proteomics )
5.     Bingnan Han, Fred Stevens and Claudia S. Maier. Design, Synthesis,and Application of a Hydrazide-Functionalized Isotope-Coded AffinityTag (HICAT) for the Quantification of Oxylid Protein Conjugates. Anal.Chem.(Article); 2007; 79(9); 3342-3354.
6.     Juan Chavez, Jianyong Wu, Bingnan Han, Woon-Gye Chung, andClaudia S. Maier. New Role for an Old Probe: Affinity Labeling ofOxylipid Protein Conjugates byN’-Aminooxymethylcarbonylhydrdrazino-D-biotin. Anal. Chem. 78 (19),6847 -6854, 2006.
7.     Ramaswamy AV, Flatt PM, Edwards DJ, Simmons TL, Han B andGerwick WH. The secondary metabolites and biosynthetic gene clustersof marine cyanobacteria. Applications in biotechnology. Frontiersin Marine Biotechnology (2006), 175-224.
8.     Bingnan Han, Harald Gross, Douglas E. Goeger, Susan L. Mooberry,and William H. Gerwick. Aurilides B and C, Cancer Cell Toxins from a PapuaNew Guinea Collection of the Marine Cyanobacterium Lyngbya majuscule. J. Nat.Prod. (Article), 2006, 69, 572-575.
9.      Bingnan Han, Kerry L. McPhail, Harald Gross, Doug Goeger, SusanMooberry, and William H. Gerwick. Isolation and Structure of FiveLyngbyabellin Derivatives from a Papua New Guinea Collection of the
Marine Cyanobacterium Lyngbya majuscule. Tetrahedron (Article),2005, 61, 11723-11729.
10.  Bingnan Han, Doug Goeger, Claudia S. Maier, and William H. Gerwick.
The Wewakpeptins, Cyclic Depsipeptides from a Papua New GuineaCollection of the Marine Cyanobacterium Lyngbyasemiplena. J. Org.Chem. (Article), 2005, 70 (8), 3133-3139.
11.     Bingnan Han, Kerry L. McPhail, Alessia Ligresti, Vincenzo Di Marzo,and William H. Gerwick. Semiplenamides A-G, Fatty Acid Amidesfrom a Papua New Guinea Collection of the Marine CyanobacteriumLyngabya semiplena. J. Nat. Prod. (Article), 2003, 66, 1364-1368.
 

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