MA, Zhong-Jun


Ma Zhongjun
Assoc. Professor, Department of Ocean Science and Engineering, Zhejiang University
Phone: +86 571 8820 8540
Fax:   +86 571 8820 8540
Office: Rm 323,
The Ocean Hall, Zhejiang University,
Zijingang Campus, 866 Yuhangtang Road , Hangzhou, China 310058
1.         Sep. 2000~Jun. 2003 Ph. D, Shenyang Pharmaceutical University, Shenyang, China
2.         Sep. 2001~Sep. 2002 Visiting Student, Graduate School of Pharmaceutical Sciences, The University of Tokyo
3.         Sep. 1994~Jul. 1998 B. S. Shenyang Pharmaceutical University, Shenyang, China
Working Experience
1.         Jun. 2011~ Associate Professor, Department of Ocean Science and Engineering, Zhejiang university
2.         Oct. 2006~ Jun. 2011 Associate Professor, School of Pharmaceutical Sciences, Zhejiang University, Zhejiang university
3.         Jul. 2005~Sep. 2006 Postdoctoral Fellow, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, USA
4.         Nov. 2003~Jun. 2005 Postdoctoral Fellow, Brain Research Center, University of British Columbia, Vancouver, Canada
Research Interests
My current research programs are focused on the discovery and mechanistic characterization of bioactive natural products. My major research effort is to discover the bioactive natural products by LC-MS and NMR techniques. Moreover, the research of the action mechanisms of the active ingredients was also an important part of the program.
Current Projects
1.         Michael addition acceptors with natural origin and their bioactivities.
2.          Novel active ingredients from marine microbes
3.          Novel targets of the active chemical constituents.
Publication List
1.       Xiaoyu Zhang, Liping Luo, Zhongjun Ma*. A deuterium-labelling mass spectrometry-tandem diode-array detector screening method for rapid discovery of naturally occurring electrophiles. Anal Bioanal Chem, 2011, 400 (11): 3463-3471.
2.       Jinzhong Xu, Juan Lu, Fang Sun, Huanzhang Zhu, Lijun Wang, Xiaoyu Zhang, Zhongjun Ma*. Terpenoids from Tripterygium wilfordii. Phytochemistry, 2011, 72: 1482-1487.
3.       Lijun Wang, Guodong Lou, Zhongjun Ma*, Xueming Liu. Chemical constituents with antioxidant activities from litchi (Litchi chinensis Sonn.) seeds. Food Chemistry, 2011, 126: 1081-1087.
4.       Fang Sun, Liming Shen, Zhongjun Ma*. Screening for ligands of human aromatase from mulberry (Mori alba L.) leaf by using high-performance liquid chromatography/tandem mass spectrometry. Food Chemistry, 2011, 126: 1337-1343.
5.       Lijun Wang, Fang Sun, Xiaoyu Zhang, Zhongjun Ma*, Lin Cheng. A secoiridoid with quinone reductase inducing activity from Cortex fraxini. Fitoterapia, 2010, 81: 834-837.
6.       Xiaoyu Zhang, Xiaofeng Zhao, Zhongjun Ma*. PYDDT, a novel phase 2 enzymes inducer, activates Keap1-Nrf2 pathway via depleting the cellular level of glutathione. Toxcol Lett, 2010, 199 (1): 93-101.
7.       Xiaoyu Zhang, Zhongjun Ma*. A new fluorescein isothiocyanate-based screening method for the rapid discovery of electrophilic compounds. Anal Methods, 2010, 2: 1472-1478.
8.       Xiaoyu Zhang, Zhongjun Ma*. Characterization of bioactive thiophenes from the dichloromethane extract of Echinops grijisii as Michael addition acceptors. Anal Bioanal Chem, 2010, 397: 1975–1984.
9.       Zhongjun Ma, Xiaoyu Zhang. Seven new benzeneacetic acid derivatives and their quinone reductase activity from Eurycorymbus cavaleriei. Phytochemistry Letters, 2009, 2 (4): 152-158..
10.   Zhongjun Ma, Min Zhang, Zhihang Song. Characterization of tanshinones with quinone reductase induction activity from radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2009, 23 (18): 2857-2866.
11.   Zhongjun Ma, Zhaoke Meng, Peng Zhang. Chemical constituents from the radix of Curcuma wenyujin. Fitoterapia, 2009, 80 (6): 374-376.
12.   Lin Cheng, Xiaoyu Zhang, Min Zhang, Peng Zhang, Zhihang Song, Zhongjun Ma*, Yiyu Cheng, Haibin Qu. Characterization of chemopreventive agents from the dichloromethane extract of Eurycorymbus cavaleriei by liquid chromatography-ion trap mass spectrometry. Journal of Chromatography A, 2009, 1216: 4859-4867.
13.   Lin Cheng, Min Zhang, Peng Zhang, Zhongjun Ma*, Haibin Qu. Silver complexation and tandem mass spectrometry for differentiation of triterpenoid saponins from the roots of Pulsatilla chinensis (Bunge) Regel. Rapid Communications in Mass Spectrometry, 2008, 22: 3783-3790.
14.   Peng Zhang, Wei Huang, Zhihang Song, Min Zhang, Lin Cheng, Yiyu Cheng, Haibin Qu, Zhongjun Ma*. Cytotoxic diterpenes from the radix of Curcuma wenyujin. Phytochemistry Letters, 2008, 1 (2): 103-106.
15.   Lin Cheng, Zhihang Song, Peng Zhang, Haibin Qu, Zhongjun Ma*. A novel meroterpene from Eurycorymbus cavaleriei. Helvetica Chimica Acta, 2008, 91 (9): 1659-1661.
16.   Wei Huang, Peng Zhang, Yecheng Jin, Qiang Shi, Yiyu Cheng, Haibin Qu, Zhongjun Ma*. Diterpenes from the root tuber of Curcuma wenyujin. Helvetica Chimica Acta, 2008, 91 (5): 944-950.
17.   Wenrong Jin, Qiang Shi, Chengtao Hong, Yiyu Cheng, Zhongjun Ma*, Haibin Qu. Cytotoxic properties of thiophenes from Echinops grijisii Hance. Phytomedicine, 2008, 15: 768-774.

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